Does DHEA have any side effects?

DHEA is a natural steroid that is produced in the adrenal glands, gonads, and in the brain (and therefore it is identified as a neurosteroid), and mediates various actions in the body and brain. Because it is natural to the body, there are not expected to be significant side effects at the doses we administer; however as with all such products, the consumer should report any unusual effects promptly to their physician or caregiver.

Why start at 100mg DHEA?

In our experience, 100 mg is the optimal dose for the support of treatment of addiction, while lower doses do not have a significant effect. Our regimen uses 100 mg as the initial dose; yet during treatment, dynamic monitoring of serum levels of DHEA and its metabolite, DHEA-S, is required to reach the ultimate dose that enables optimal patient response.

Can DHEA take the place of traditional rehab?

DHEA is given as part of the complex system of treatments provided in rehabilitation centers, and needs to be taken under strict medical supervision and only in the context of such treatment.

Can DHEA be given to any patient treated at a rehabilitation center?

DHEA cannot be taken by men with enlarged prostate or prostate cancer, or by menopausal or post-menopausal women. In addition, patients treated for sex addiction require closer supervision. This is based on research which suggests that DHEA may adversely affect those conditions.

What does current research on DHEA show?

Research has demonstrated that supplementation with DHEA in the context of an overall treatment program may help support reducing the severity of symptoms of drug addiction, including reduction of depression and anxiety, increase cognitive strength, and decrease the probability of relapse to addiction.

For which other diseases was DHEA found to be effective?

Research suggests that supplementation with DHEA may improve symptoms of depression, anxiety, phobias, schizophrenia, and more.

Can DHEA administration be discontinued after the rehabilitation period?

Initial studies show that DHEA is only required during the rehabilitation period. However, patients who have concluded the rehabilitation period, and need to continue with this supporting treatment in order to stay drug-free (as determined by our specialists), may do so. However, in this case, DHEA should be prescribed by our doctors, since, in Canada, DHEA is not commercially manufactured as a food supplement like in other countries and is not available in health food stores.

How long does it take for DHEA to exert its effects?

In the context of an addiction treatment program, supplementation with DHEA may show effects relatively rapidly, enhancing a general feeling of well-being from the initial stage. Yet a carefully structured program is required to insure that these effects manifest themselves and continue during a period of long-term rehabilitation. Non-supervised or non-personalized taking of DHEA (i.e., too high or too low a dose) can either be ineffective, or yield undesired effects.

Does DHEA treat detoxification or decrease long term relapse?

DHEA is proved to treat both detox and long term substance abuse rehabilitation demonstrated by Ohana et al. Beside published data we have hundreds to treated addicts which enrolled improvement with DHEA add-on. In Retorno rehabilitation center (a leading rehabilitation in Israel), DHEA is given routinely.

Does DHEA have equal effect as Methadone od subutex?

Methadone is not a drug for rehabilitation because does not hill substance use. Rater it is a maintenance life-long treatment that replace dependence on methadone with dependence to heroine (both are high affinity selective agonist for mu receptor- the receptor that cause substance dependence. Vice versa DHEA is a material that acts on the reward system for hilling substance use. Its mechanism is by being a neurosteroid, a backbone of a steroid but act on specific receptors in the central nervous system (brain) – all of which relate to control of mood and, as we have found, increase neurogenesis in the hippocampus and by that increase the capacity to earn and embed new memories from the rehabilitation enriched environment and replace the addict's rumination of drug-use memories as (addiction in a memory- related reward disorder, a usurpation of the reward control by substance-related memories)

Taking DHEA as a steroid, does one expect sex side-effects?

DHEA in a week androgen with no side effect using up to 100 mg a day. For postpartum it is used even in 400 mg a day with not notices side effects. We use it in 100mg a day. It was reported by Strous and colleagues not affecting lingering hormonal fluctuation.

Does DHEA has cross-reactivity with anti-depressant or anxiolytic drugs?

DHEA is a superior antidepressant as proved previously by Wolkowitz and colleages, and many more recently by the same researcher. In our hands it replaced AD used during withdrawal and decrease anxiety. It also has no counter- indication to interfere with sleep. On the contrary, many patients report a better sleep

Is DHEA considered a medication?

Each country has its one regulation. In many countries, DHEA is not a clinical drug but an add-on naturalistic treatment (food supplement) to boost rehabilitation and decrease relapse rate to substance usage. For example, in the USA, DHEA is considered a dietary supplement under the Dietary Supplements and Health Education Act of 1994. Health Canada classifies DHEA as a control drug and therefore in Canada, DHEA is only available by prescription.

What ensure DHEA as a novel medication to attenuate drug relapse to drug usage?

DHEA is the first epigenetic medication for addiction, as show our recent groundbreaking publication. This means it can re-program the genome to restore the subject's previous ability of decision making if to use the drug.